Histamine Manager contains 20,000 HDU per serving of the active enzyme Diamine Oxidase (DAO) responsible for neutralizing histamine in your digestive tract. Histamine-containing foods may not be the only culprit of your symptoms. Histamine is naturally created during digestion. Due to genetics or autoimmune conditions, your body may not make enough DAO to degrade the histamine in your digestive tract. Supplement with Histamine Manager to increase available DAO during digestion. Eat and drink with ease and confidence. Histamine Manager allows you to enjoy histamine-releasing foods and -more especially- red wine. If you are sensitive to histamine, you know that red wine contains histamine, liberates histamine, and blocks the action of DAO. If you want to avoid a histamine reaction, headache, or allergy-like reaction, take 1-2 capsules up to 15 minutes before you eat a meal, snack or drink alcohol. Diamine Oxidase (DAO) is your body’s digestive enzyme that breaks down histamine in food or histamine created during digestion. Signs of histamine intolerance are gas, bloating, headaches, sinus issues, food sensitivities. Following a low-histamine diet may not be enough to alleviate all histamine reactions especially when eating histamine-rich foods. A histamine imbalance may be a key factor if you suspect MCAS (Mast Cell Activation Syndrome), SIBO (Small Intestinal Bowel Overgrowth), Leaky Gut, hormone imbalance or overactive immune system. Histamine Manager does not contain: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or artificial preservatives. 100% Money-Back Guarantee – if Histamine Manager is not right for you or does not meet your expectations, simply return it for a full refund of the purchase price. Note: Histamine Manager does not manage or address antibody-related or IgE-related food allergies.